ethyl 4-chloronicotinate
4-Chloro-nicotinic acid ethyl ester
CAS: 37831-62-2
Molecular Formula: C8H8ClNO2
ethyl 4-chloronicotinate - Names and Identifiers
ethyl 4-chloronicotinate - Physico-chemical Properties
| Molecular Formula | C8H8ClNO2 |
| Molar Mass | 185.61 |
| Density | 1.245±0.06 g/cm3(Predicted) |
| Boling Point | 70-76℃/0.1Torr |
| Flash Point | 102.047 °C |
| pKa | 1.81±0.10(Predicted) |
ethyl 4-chloronicotinate - Risk and Safety
| UN IDs | 2735 |
| Hazard Class | 8 |
| Packing Group | Ⅲ |
ethyl 4-chloronicotinate - Introduction
4-Chloro-nicotinic acid ethyl ester is an organic compound with the chemical formula C8H8ClNO2. It is a colorless to yellowish liquid with a peculiar odor.
4-Chloro-nicotinic acid ethyl ester is mainly used as reagent and intermediate in organic synthesis. It is widely used in the preparation of various nitrogen-containing organic compounds, such as pharmaceuticals, pesticides, dyes and functional materials. It also has some applications in the field of medicine, which can be used to synthesize anti-tumor, anti-inflammatory and antibacterial drugs.
The method of preparing 4-Chloro-nicotinic acid ethyl ester can be achieved by esterifying 4-chloro nicotinic acid with ethanol. The reaction is generally carried out under acidic conditions, and sulfuric acid or the like can be selected as a catalyst.
Regarding safety information, 4-Chloro-nicotinic acid ethyl ester may be dangerous in the presence of high temperatures, ignition sources or oxidants. It is irritating and corrosive and should be rinsed with water immediately after contact with skin and eyes. During use and storage, attention should be paid to fire prevention and ventilation, and contact with strong oxidants and acidic substances should be avoided.
Always wear appropriate personal protective equipment such as laboratory gloves, safety glasses, and laboratory coats when handling this compound. To ensure safety, use 4-Chloro-nicotinic acid ethyl ester only under the guidance of experienced personnel.
4-Chloro-nicotinic acid ethyl ester is mainly used as reagent and intermediate in organic synthesis. It is widely used in the preparation of various nitrogen-containing organic compounds, such as pharmaceuticals, pesticides, dyes and functional materials. It also has some applications in the field of medicine, which can be used to synthesize anti-tumor, anti-inflammatory and antibacterial drugs.
The method of preparing 4-Chloro-nicotinic acid ethyl ester can be achieved by esterifying 4-chloro nicotinic acid with ethanol. The reaction is generally carried out under acidic conditions, and sulfuric acid or the like can be selected as a catalyst.
Regarding safety information, 4-Chloro-nicotinic acid ethyl ester may be dangerous in the presence of high temperatures, ignition sources or oxidants. It is irritating and corrosive and should be rinsed with water immediately after contact with skin and eyes. During use and storage, attention should be paid to fire prevention and ventilation, and contact with strong oxidants and acidic substances should be avoided.
Always wear appropriate personal protective equipment such as laboratory gloves, safety glasses, and laboratory coats when handling this compound. To ensure safety, use 4-Chloro-nicotinic acid ethyl ester only under the guidance of experienced personnel.
Last Update：2024-04-09 20:02:46
